The University of North Carolina at Chapel Hill is a world leader in nanomedicine and drug delivery research. It houses a Center for Nanotechnology in Drug Delivery (CNDD), a joint venture between the UNC Eshelman School of Pharmacy and the UNC School of Medicine.
Prior to being further tested to assess its in vitro biological properties and in vivo compatibility, any novel nanomedicine must undergo a thorough physicochemical characterization. Because nanomedicines are commonly composed of biocompatible and biodegradable polymers as well as cells and other components of biological fluids, characterization requirements and approaches for nanomedicines set them apart from nanomaterials used in other fields. Additionally, nanomedicines are developed for use and storage within certain range of temperatures, osmotic pressure, and pH. Since special knowledge and methodologies are required for nanomedicines characterization, establishment of specialized facilities for this purpose is warranted.
NCore offers researchers an opportunity for in-depth characterization of nanomaterials and carrier-mediated agents (CMA) including:
- chemical composition
- number average molar mass (Mn)
- weight average molar mass (Mw)
- molecular weight distribution
- gyration radius
- size distribution
- surface charge
- count number of nanoparticles
- solubility (second virial coefficient)
- isotope analysis
- analytical evaluation of nanoparticle encapsulated and released drug or agent stability and released rates
- endotoxin contaminant/sterility study
- UV/Vis spectroscopy
- UV-temperature correlation, etc.