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Size, concentration and surface charge

Nanoparticle Tracking Analysis

ZetaView® QUATT (Particle Metrix Inc.)

  • Measuring hydrodynamic number average particle size, concentration and surface charge.
  • Selective analysis of size sub-populations in the samples.
  • Enhanced fluorescence measurement capability. Multi-wavelength F-NTA allows assessing the purity of exosomes isolation, phenotyping of EVS, measurement of sEV dsDNA.
  • Virus and Virus like particles characterization, defined virions can be stained and thus identified from complex samples such as patient material. F-NTA can be used to analyze the amount of successfully loaded (nucleic acid-containing) virions.

Laser wavelength: 405 nm, 488 nm, 520 nm, 640 nm

Key Applications

  • Extracellular Vesicles
  • Nanoparticles
  • SPIONs
  • Virus & Virus-Like-Particles (VLPs)
  • Quantum-dots

Dynamic Light Scattering/Zeta Potential meter

Zetasizer Nano ZS (Malvern Panalytical, Ltd, UK)

  • Simple, rapid, repeatable and non-destructive technique
  • Low volume sample measurement (for valuable proteins and biopolymer samples)
  • Size measurement at low concentrations

Light Source: 633 nm

Accuracy: Better than +/-2% on NIST traceable latex standards 0.12µm·cm/V·s for aqueous systems using NIST, SRM1980 standard reference material

Size range (diameter): 0.3 nm to 10 μm

Size range for Zeta potential: 3.8 nm to 100 μm

Key applications:

  • Proteins and polymer analysis
  • Size determination
  • Polydispersity index determination
  • Zeta potential measurements